Preheat the air fryer. Set your air fryer to 380°F (193°C). A preheated basket helps build that crisp exterior.
Even out the chicken. If your chicken breasts are very thick on one end, place them between two sheets of parchment and pound the thickest part with a meat mallet or rolling pin to about 3/4–1 inch thickness. This helps them cook evenly.
Pat dry. Use paper towels to remove surface moisture. Dry chicken equals better browning and crispiness.
Season. Rub chicken with olive oil.
In a small bowl, mix salt, pepper, garlic powder, onion powder, paprika, and oregano. Sprinkle evenly on both sides and press to adhere. For a crunch boost, pat on the oiled panko mixture.
Air fry. Place chicken breasts in a single layer in the basket.
Don’t overlap. Cook for 8–10 minutes, flip, then cook another 6–8 minutes. Total time is usually 14–18 minutes depending on thickness.
Check doneness. Use an instant-read thermometer in the thickest part. You’re aiming for 160–162°F (71°C) in the basket; carryover heat will bring it to 165°F (74°C) while resting.
Rest and serve. Let the chicken rest for 5 minutes.
Slice against the grain. Finish with a squeeze of lemon if you like.